Structure of PDB 2oo0 Chain B

Receptor sequence
>2oo0B (length=418) Species: 9606 (Homo sapiens) [Search protein sequence]
GENLYFQSLMNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFY
VADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCAS
KTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMK
VARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDV
VGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGS
EDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNII
AKKIVLEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSS
IWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPT
IYYVMSGPAWQLMQQFQN
3D structure
PDB2oo0 A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K69 H197 E274
Catalytic site (residue number reindexed from 1) K78 H206 E283
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B A67 K69 D88 H197 S200 G237 E274 G276 R277 Y389 A76 K78 D97 H206 S209 G246 E283 G285 R286 Y385 MOAD: Kd=0.05uM
BS02 XAP B C164 D332 Y389 C173 D328 Y385 MOAD: Ki=1.4nM
BS03 N2P B G201 V244 K245 L246 G210 V253 K254 L255
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001822 kidney development
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0033387 putrescine biosynthetic process from ornithine
GO:0042176 regulation of protein catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2oo0, PDBe:2oo0, PDBj:2oo0
PDBsum2oo0
PubMed17407445
UniProtP11926|DCOR_HUMAN Ornithine decarboxylase (Gene Name=ODC1)

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