Structure of PDB 2oi6 Chain B

Receptor sequence
>2oi6B (length=452) Species: 562 (Escherichia coli) [Search protein sequence]
NNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVH
LVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILML
YGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGI
VEHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDII
ALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGV
MLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSV
IGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKK
ARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVF
VGSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRP
VK
3D structure
PDB2oi6 Structure of the E. coli bifunctional GlmU acetyltransferase active site with substrates and products.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R18
Catalytic site (residue number reindexed from 1) R16
Enzyme Commision number 2.3.1.157: glucosamine-1-phosphate N-acetyltransferase.
2.7.7.23: UDP-N-acetylglucosamine diphosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GP1 B H363 N377 H361 N375
BS02 MG B D105 N227 D103 N225
BS03 COA B G404 S405 A422 A423 R440 G402 S403 A420 A421 R438
BS04 UD1 B L11 A12 A13 G14 Q76 Q79 G81 T82 Y103 D105 Y139 G140 E154 N169 T170 T199 N227 L9 A10 A11 G12 Q74 Q77 G79 T80 Y101 D103 Y137 G138 E152 N167 T168 T197 N225
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0016779 nucleotidyltransferase activity
GO:0019134 glucosamine-1-phosphate N-acetyltransferase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0008360 regulation of cell shape
GO:0009245 lipid A biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2oi6, PDBe:2oi6, PDBj:2oi6
PDBsum2oi6
PubMed17473010
UniProtP0ACC7|GLMU_ECOLI Bifunctional protein GlmU (Gene Name=glmU)

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