Structure of PDB 2ofv Chain B

Receptor sequence
>2ofvB (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
PWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGAFL
AEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKL
TINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLA
RLIEDPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPIQNLE
GYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFT
3D structure
PDB2ofv Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D364 R366 A368 N369 D382
Catalytic site (residue number reindexed from 1) D128 R130 A132 N133 D146
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 242 B V259 A271 K273 E288 L291 M292 L300 I314 T316 Y318 M319 L371 I380 A381 D382 F383 V28 A40 K42 E52 L55 M56 L64 I78 T80 Y82 M83 L135 I144 A145 D146 F147 MOAD: ic50=0.2nM
BindingDB: IC50=0.2nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2ofv, PDBe:2ofv, PDBj:2ofv
PDBsum2ofv
PubMed16970394
UniProtP06239|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)

[Back to BioLiP]