Structure of PDB 2oa8 Chain B

Receptor sequence
>2oa8B (length=226) Species: 10090 (Mus musculus) [Search protein sequence]
QTLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGH
PPPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDN
LAILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCV
DSIAALKALEQASRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQW
KPQALLQWVDEHARPFSTVKPMYGTA
3D structure
PDB2oa8 The Crystal Structure of TREX1 Explains the 3' Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B E20 A21 G23 L24 G80 A81 H124 N125 Y129 I156 S176 Y177 S178 L179 E17 A18 G20 L21 G77 A78 H121 N122 Y126 I153 S166 Y167 S168 L169
BS02 CA B D18 E20 D200 D15 E17 D190
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2oa8, PDBe:2oa8, PDBj:2oa8
PDBsum2oa8
PubMed17293595
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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