Structure of PDB 2o9i Chain B

Receptor sequence
>2o9iB (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSREEAAKWSQVRK
DLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGI
ISFAKVISYFRDLPIEDQISLLKGAAFELSQLRFNTVFNAETGTWECGRL
SYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRP
GVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSIN
AQHTQRLLRIQDIHPFATPLMQELFGITG
3D structure
PDB2o9i Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I1255 K1259 I1269 E1270 Q1272 I1273 K1277 E1427 I101 K105 I115 E116 Q118 I119 K123 E273
BS02 444 B L1209 M1243 Q1285 F1288 W1299 Y1306 M1323 H1327 H1407 L1411 F1420 L55 M89 Q131 F134 W145 Y152 M169 H173 H253 L257 F266 BindingDB: EC50=36nM,IC50=40nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2o9i, PDBe:2o9i, PDBj:2o9i
PDBsum2o9i
PubMed17215127
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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