Structure of PDB 2o8f Chain B

Receptor sequence
>2o8fB (length=933) Species: 9606 (Homo sapiens) [Search protein sequence]
PTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMR
KWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGF
PEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRR
EICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEDSSHTRAYGVCFVD
TSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSKETKTILKSS
LSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIVMLPQVLKGMT
SESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLD
SDTVSKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKR
LLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLL
SKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKII
GIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKAR
KTGLITPKAGFSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIG
RNRYQLEIPENFTTRNLPEYELKSTKKGCKRYWTKTIEKKLANLINAEER
RDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPM
CRPVILLPEDTPPFLELKGSRHPCITDDFIPNDILIGCEEEEQENKAYCV
LVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGST
FFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETI
KCRTLFSTHYHSLVEDYSQNVAVRLGHMACMTFLYKFIKGACPKSYGFNA
ARLANLPEEVIQKGHRKAREFEKMNQSLRLFRE
3D structure
PDB2o8f Structure of the Human MutSalpha DNA Lesion Recognition Complex.
ChainB
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B T407 G409 Q485 V508 V509 R511 Y845 K997 T46 G48 Q124 V147 V148 R150 Y473 K623
BS02 dna B F432 E434 V450 M452 K453 G460 P462 R468 Y469 I972 T999 K1000 F71 E73 V89 M91 K92 G99 P101 R107 Y108 I599 T625 K626
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:2o8f, PDBe:2o8f, PDBj:2o8f
PDBsum2o8f
PubMed17531815
UniProtP52701|MSH6_HUMAN DNA mismatch repair protein Msh6 (Gene Name=MSH6)

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