Structure of PDB 2o8b Chain B

Receptor sequence

>2o8bB (length=930) Species: 9606 (Homo sapiens) [Search protein sequence]

PTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMR
KWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGF
PEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRR
EICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEDSSHTRAYGVCFVD
TSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSKETKTILKSS
LSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIVMLPQVLKGMT
SESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPLD
SDTVSKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKR
LLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLL
SKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKII
GIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHEKAR
KTGLITPKAGFSDYDQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIG
RNRYQLEIPENFTTRNLPEYELKSTKKGCKRYWTKTIEKKLANLINAEER
RDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYSRGGDGPM
CRPVILLPEDTPPFLELKGSRHPCGDDFIPNDILIGCEEEEQKAYCVLVT
GPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGSTFFV
ELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCR
TLFSTHYHSLVEDYSQNVAVRLGHMACMTFLYKFIKGACPKSYGFNAARL
ANLPEEVIQKGHRKAREFEKMNQSLRLFRE

3D structure

PDB

2o8b Structure of the Human MutSalpha DNA Lesion Recognition Complex.

Chain

Resolution

2.75 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	T407 P408 G409 V429 G430 K431 F432 P489 V508 V509 R511 Y845	T46 P47 G48 V68 G69 K70 F71 P128 V147 V148 R150 Y473
BS02	dna	B	F432 E434 L449 V450 M452 K453 G460 P462 R468 Y469 W970 T999 K1000 K1004	F71 E73 L88 V89 M91 K92 G99 P101 R107 Y108 W597 T625 K626 K630
BS03	ADP	B	F1108 I1109 N1136 M1137 G1138 G1139 K1140 S1141 T1142 Y1287	F728 I729 N753 M754 G755 G756 K757 S758 T759 Y882

Gene Ontology

	Molecular Function
GO:0005524	ATP binding
GO:0030983	mismatched DNA binding
GO:0140664	ATP-dependent DNA damage sensor activity

	Biological Process
GO:0006298	mismatch repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2o8b, PDBe:2o8b, PDBj:2o8b
PDBsum	2o8b
PubMed	17531815
UniProt	P52701\|MSH6_HUMAN DNA mismatch repair protein Msh6 (Gene Name=MSH6)

[Back to BioLiP]