Structure of PDB 2o4g Chain B

Receptor sequence
>2o4gB (length=217) Species: 10090 (Mus musculus) [Search protein sequence]
GHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPPPVP
RPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILL
RAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAA
LKALEQAKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALLQ
WVDEHARPFSTVKPMYG
3D structure
PDB2o4g Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains.
ChainB
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D18 E20 D200 D10 E12 D183
BS02 TMP B D18 E20 A21 L24 I84 Y129 H195 D10 E12 A13 L16 I76 Y121 H178
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2o4g, PDBe:2o4g, PDBj:2o4g
PDBsum2o4g
PubMed17355961
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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