Structure of PDB 2o3k Chain B

Receptor sequence
>2o3kB (length=153) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MASKWDQKGMDIAYEEALLGYKEGGVPIGGCLINNKDGSVLGRGHNMRFQ
KGSATLHGEISTLENCGRLEGKVYKDTTLYTTLSPCEMCTGAIIMYGIPR
CVIGENVNFKSKGEKYLQTRGHEVVVVDDERCKKLMKQFIDERPQDWFED
IGE
3D structure
PDB2o3k Crystal structure of Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H262 E264 S289 C291 C294
Catalytic site (residue number reindexed from 1) H57 E59 S84 C86 C89
Enzyme Commision number 3.5.4.1: cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H262 C291 C294 H57 C86 C89
BS02 HPY B I233 H262 E264 C291 D355 I28 H57 E59 C86 D150
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004131 cytosine deaminase activity
GO:0008270 zinc ion binding
GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
GO:0016787 hydrolase activity
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0019239 deaminase activity
GO:0046872 metal ion binding
Biological Process
GO:0008655 pyrimidine-containing compound salvage
GO:0019858 cytosine metabolic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0044206 UMP salvage
GO:0046087 cytidine metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:2o3k, PDBe:2o3k, PDBj:2o3k
PDBsum2o3k
PubMed
UniProtQ12178|FCY1_YEAST Cytosine deaminase (Gene Name=FCY1)

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