Structure of PDB 2o05 Chain B

Receptor sequence
>2o05B (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
AIREGWFRETCSLWPGQALSLQVEQLLHHRRSRYQDILVFRSKTYGNVLV
LDGVIQCTERDEFSYQEMIANLPLCSHPNPRKVLIIGGGDGGVLREVVKH
PSVESVVQCEIDEDVIQVSKKFLPGMAIGYSSSKLTLHVGDGFEFMKQNQ
DAFDVIITDSSDPMGPAESLFKESYYQLMKTALKEDGVLCCQGECQWLHL
DLIKEMRQFCQSLFPVVAYAYCTIPTYPSGQIGFMLCSKNPSTNFQEPVQ
PLTQQQVAQMQLKYYNSDVHRAAFVLPEFARKALND
3D structure
PDB2o05 Structure and mechanism of spermidine synthases.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MTA B G101 G103 D104 E124 I125 G154 D155 G156 S174 S175 P180 A181 G87 G89 D90 E110 I111 G140 D141 G142 S160 S161 P166 A167
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006595 polyamine metabolic process
GO:0008295 spermidine biosynthetic process
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2o05, PDBe:2o05, PDBj:2o05
PDBsum2o05
PubMed17585781
UniProtP19623|SPEE_HUMAN Spermidine synthase (Gene Name=SRM)

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