Structure of PDB 2nyr Chain B

Receptor sequence
>2nyrB (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
PSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDL
ATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRV
VVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALS
GKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEV
DRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTRFHFQGPCG
TTLPEALA
3D structure
PDB2nyr Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin.
ChainB
Resolution2.06 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P68 T69 F70 R71 N141 D143 H158
Catalytic site (residue number reindexed from 1) P33 T34 F35 R36 N106 D108 H123
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SVR B F70 R71 A86 Y102 R105 H158 V221 F223 G224 E225 N226 L232 V254 Y255 F35 R36 A51 Y67 R70 H123 V186 F188 G189 E190 N191 L197 V219 Y220 PDBbind-CN: -logKd/Ki=4.66,IC50=22uM
BindingDB: IC50=25000nM
BS02 ZN B C166 C169 C207 C212 C131 C134 C172 C177
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:2nyr, PDBe:2nyr, PDBj:2nyr
PDBsum2nyr
PubMed17355872
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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