Structure of PDB 2nwx Chain B

Receptor sequence
>2nwxB (length=396) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence]
VLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPI
VFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGA
GIHLAVGPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYLMN
SENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAEQ
GVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDAML
TAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQGV
CTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLHSV
GLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE
3D structure
PDB2nwx Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
ChainB
Resolution3.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ASP B R276 S278 G354 V355 P356 G357 G359 D394 R397 T398 N401 R256 S258 G334 V335 P336 G337 G339 D374 R377 T378 N381 BindingDB: Kd=1.000000nM
BS02 NA B T308 M311 S349 I350 G351 T352 T288 M291 S329 I330 G331 T332
BS03 NA B G306 A307 N310 M311 N401 V402 D405 G286 A287 N290 M291 N381 V382 D385
Gene Ontology
Molecular Function
GO:0005283 amino acid:sodium symporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015501 glutamate:sodium symporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0035725 sodium ion transmembrane transport
GO:0046942 carboxylic acid transport
GO:0070207 protein homotrimerization
GO:0070778 L-aspartate transmembrane transport
GO:0140009 L-aspartate import across plasma membrane
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:2nwx, PDBe:2nwx, PDBj:2nwx
PDBsum2nwx
PubMed17230192
UniProtO59010|GLT_PYRHO Glutamate transporter homolog (Gene Name=PH1295)

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