Structure of PDB 2nww Chain B

Receptor sequence
>2nwwB (length=407) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence]
YPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVM
PIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNP
GAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAI
ILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGV
FALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPI
SFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATI
NMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAG
AIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGT
AIVAKTE
3D structure
PDB2nww Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
ChainB
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TB1 B R276 S277 S278 M311 T314 G359 D394 R397 T398 R267 S268 S269 M302 T305 G350 D385 R388 T389 BindingDB: Kd=100nM
Gene Ontology
Molecular Function
GO:0005283 amino acid:sodium symporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015501 glutamate:sodium symporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0035725 sodium ion transmembrane transport
GO:0046942 carboxylic acid transport
GO:0070207 protein homotrimerization
GO:0070778 L-aspartate transmembrane transport
GO:0140009 L-aspartate import across plasma membrane
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2nww, PDBe:2nww, PDBj:2nww
PDBsum2nww
PubMed17230192
UniProtO59010|GLT_PYRHO Glutamate transporter homolog (Gene Name=PH1295)

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