Structure of PDB 2nwl Chain B

Receptor sequence
>2nwlB (length=398) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence]
YPVLIKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVM
PIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNP
GAGIHLAVGPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILGIAITYL
MNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMA
EQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKHAKDA
MLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQ
GVCTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIMLAMVLH
SVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE
3D structure
PDB2nwl Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
ChainB
Resolution2.96 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ASP B R276 S278 T314 G354 V355 G359 D394 R397 T398 N401 R258 S260 T296 G336 V337 G341 D376 R379 T380 N383 BindingDB: Kd=1.000000nM
Gene Ontology
Molecular Function
GO:0005283 amino acid:sodium symporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015501 glutamate:sodium symporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0035725 sodium ion transmembrane transport
GO:0046942 carboxylic acid transport
GO:0070207 protein homotrimerization
GO:0070778 L-aspartate transmembrane transport
GO:0140009 L-aspartate import across plasma membrane
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2nwl, PDBe:2nwl, PDBj:2nwl
PDBsum2nwl
PubMed17230192
UniProtO59010|GLT_PYRHO Glutamate transporter homolog (Gene Name=PH1295)

[Back to BioLiP]