Structure of PDB 2nqa Chain B

Receptor sequence
>2nqaB (length=318) Species: 9606 (Homo sapiens) [Search protein sequence]
NALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGPQTQGI
IWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYR
VVPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQG
NEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGSEFYDLKKPPANL
YQIIRKALCAGSLLGCSIDVYSAAEAEAITSQKLVKSHAYSVTGVEEVNF
QGHPEKLIRLRNPWGEEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFW
MSLSDFVRQFSRLEICNL
3D structure
PDB2nqa Structure of Human Calpain 8
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q99 C105 H262 N286 W288
Catalytic site (residue number reindexed from 1) Q76 C82 H238 N262 W264
Enzyme Commision number 3.4.22.53: calpain-2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N189 G190 N166 G167
BS02 peptide B G103 C105 G197 S261 G80 C82 G174 S237
BS03 CA B E292 D299 V319 D321 E323 E267 D274 V294 D296 E298
BS04 CA B V89 G91 D96 E175 V66 G68 D73 E152
Gene Ontology
Molecular Function
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2nqa, PDBe:2nqa, PDBj:2nqa
PDBsum2nqa
PubMed
UniProtA6NHC0|CAN8_HUMAN Calpain-8 (Gene Name=CAPN8)

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