Structure of PDB 2npf Chain B

Receptor sequence
>2npfB (length=813) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
AFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAGITI
KSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDDFSSEVTAALRVTDGA
LVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLY
QTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQF
ATRYAKKFGVDKAKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNM
FILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDEKDLEGKALLKVVMR
KFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKNCDPK
ADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDD
LFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETA
HNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSES
GEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTA
LSKSPNKHNRIYLKAEPIDEEVSLAIENGIINPRDDFKARARIMADDYGW
DVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIKDSVVAAFQWATKEGP
IFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLADPKIQ
EPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQPLFTVKAYLPVNESFG
FTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKRHGMK
EEVPGWQEYYDKL
3D structure
PDB2npf Sordarin derivatives induce a novel conformation of the yeast ribosome translocation factor eEF2
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MOU B V488 Q490 Y521 S523 E524 V561 A562 S777 G779 T781 M796 F798 W801 V463 Q465 Y496 S498 E499 V536 A537 S748 G750 T752 M767 F769 W772
BS02 GDP B V28 D29 G31 K32 S33 T34 N158 K159 D161 S213 G214 L215 V26 D27 G29 K30 S31 T32 N133 K134 D136 S188 G189 L190
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019843 rRNA binding
GO:0042802 identical protein binding
GO:0043022 ribosome binding
GO:0051087 protein-folding chaperone binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0045901 positive regulation of translational elongation
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2npf, PDBe:2npf, PDBj:2npf
PDBsum2npf
PubMed17082187
UniProtP32324|EF2_YEAST Elongation factor 2 (Gene Name=EFT1)

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