Structure of PDB 2lsp Chain B

Receptor sequence
>2lspB (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]
KDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDV
EALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKY
NPPDHEVVAMARKLQDVFEMRFAKMPDE
3D structure
PDB2lsp Down-regulation of NF-kappa B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.
ChainB
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B W374 P375 F376 V380 L385 G386 L387 D389 D392 I393 C429 Y432 N433 H437 E438 V439 W42 P43 F44 V48 L53 G54 L55 D57 D60 I61 C97 Y100 N101 H105 E106 V107
External links
PDB RCSB:2lsp, PDBe:2lsp, PDBj:2lsp
PDBsum2lsp
PubMed22645123
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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