Structure of PDB 2jif Chain B

Receptor sequence

>2jifB (length=377) Species: 9606 (Homo sapiens)

TFTDEEMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGI
EVDPEYGGTGASFLSTVLVIEELAKVDASVAVFCEIQNTLINTLIRKHGT
EEQKATYLPQLTTEKVGSFCLSEAGAGSDSFALKTRADKEGDYYVLNGSK
MWISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPENKLGL
RASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLA
QGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAAR
LLEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFR
DAKIGTIYEGASNIQLNTIAKHIDAEY

3D structure

• PDB: 2jif Crystal Structure of Human Short-Branched Chain Acyl-Coa Dehydrogenase
• Chain: B
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): L176 S177 G293 E414 K426
• Catalytic site (residue number reindexed from 1): L121 S122 G238 E359 K371
• Enzyme Commision number: 1.3.8.5: short-chain 2-methylacyl-CoA dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	L176 S177 G182 S183 W207 I208 S209 K252 T260 N418 I419	L121 S122 G127 S128 W152 I153 S154 K197 T205 N363 I364
BS02	COS	B	S183 S185 F186 Y229 Y283 I287 L290 N291 R294 Y413 E414 G415 I419	S128 S130 F131 Y174 Y228 I232 L235 N236 R239 Y358 E359 G360 I364
BS03	FAD	B	R319 F322 L326 F329 L332 E387 W388 G391	R264 F267 L271 F274 L277 E332 W333 G336

Gene Ontology

Molecular Function

• GO:0003995 acyl-CoA dehydrogenase activity
• GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
• GO:0050660 flavin adenine dinucleotide binding

External links

• PDB: RCSB:2jif, PDBe:2jif, PDBj:2jif
• PDBsum: 2jif
• UniProt: P45954|ACDSB_HUMAN Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADSB)