Structure of PDB 2jfa Chain B

Receptor sequence
>2jfaB (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLA
QLLLILSHIRHMSNKGMEHLYSM
3D structure
PDB2jfa Structural Insights Into Corepressor Recognition by Antagonist-Bound Estrogen Receptors.
ChainB
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B L354 I358 K362 V376 E380 W383 L49 I53 K57 V71 E75 W78
BS02 RAL B L346 T347 A350 D351 E353 L354 W383 F404 M421 I424 H524 L41 T42 A45 D46 E48 L49 W78 F99 M116 I119 H219 BindingDB: IC50=1.8nM,EC50=2.4nM,Ki=0.37nM
External links
PDB RCSB:2jfa, PDBe:2jfa, PDBj:2jfa
PDBsum2jfa
PubMed17283072
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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