Structure of PDB 2j9f Chain B

Receptor sequence
>2j9fB (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]
EYGQTQKMNLFQSVTSALDNSLAKDPTAVIFGEDVAFGGVFRCTVGLRDK
YGKDRVFNTPLCEQGIVGFGIGIAVTGATAIAEIQFADYIFPAFDQIVNE
AAKYRYRSGDLFNCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVV
IPRSPFQAKGLLLSCIEDKNPCIFFEPKILYRAAAEEVPIEPYNIPLSQA
EVIQEGSDVTLVAWGTQVHVIREVASMAKEKLGVSCEVIDLRTIIPWDVD
TICKSVIKTGRLLISHEAPLTGGFASEISSTVQEECFLNLEAPISRVCGY
DTPFPHIFEPFYIPDKWKCYDALRKMINY
3D structure
PDB2j9f The Two Active Sites in Human Branched-Chain Alpha- Keto Acid Dehydrogenase Operate Independently without an Obligatory Alternating-Site Mechanism.
ChainB
Resolution1.88 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) E76 H146
Catalytic site (residue number reindexed from 1) E63 H133
Enzyme Commision number 1.2.4.4: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 THV B E46 L74 E76 Q98 Y102 H146 E33 L61 E63 Q85 Y89 H133
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:2j9f, PDBe:2j9f, PDBj:2j9f
PDBsum2j9f
PubMed17329260
UniProtP21953|ODBB_HUMAN 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (Gene Name=BCKDHB)

[Back to BioLiP]