Structure of PDB 2j83 Chain B

Receptor sequence
>2j83B (length=259) Species: 188937 (Methanosarcina acetivorans C2A) [Search protein sequence]
EIVKIPVVVHVVWNEEEENISDAQIQSQIDILNKDFRKLNSDVSQVPSVW
SNLIADLGIEFFLATKDPNGNQTTGITRTQTSVTFFTTSDEVKFASSGGE
DAWPADRYLNIWVCHVLKSEIGQDILGYAQFPGGPAETDGVVIVDAAFGT
TGTALPPFDKGRTATHEIGHWLNLYHIWGDELRFEDPCSRSDEVDDTPNQ
ADPNFGAPSYPHVSCSNGPNGDMFMNYMDYVDDKCMVMFTQGQATRVNAC
LDGPRSSFL
3D structure
PDB2j83 Substrate Specificity of a Metalloprotease of the Pappalysin Family Revealed by an Inhibitor and a Product Complex.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BAT B Q185 D186 I187 L188 G189 H228 E229 H232 H238 Y292 Q123 D124 I125 L126 G127 H166 E167 H170 H176 Y230 MOAD: ic50=61uM
PDBbind-CN: -logKd/Ki=4.21,IC50=61uM
BS02 CA B W240 E243 P249 Q262 A263 W178 E181 P187 Q200 A201
BS03 CA B D254 V256 T259 D192 V194 T197
BS04 ZN B H228 H232 H238 H166 H170 H176
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:2j83, PDBe:2j83, PDBj:2j83
PDBsum2j83
PubMed17097044
UniProtQ8TL28|ULIL_METAC Ulilysin (Gene Name=MA_3214)

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