Structure of PDB 2j0k Chain B

Receptor sequence
>2j0kB (length=612) Species: 9031 (Gallus gallus) [Search protein sequence]
RVLKVFHYFENSSEPTTWASIIRHGDATDVRGIIQKIVDCHKVKNVACYG
LRLSHLQSEEVHWLHLDMGVSNVREKFELAHPPEEWKYELRIRYLPKGFL
NQFTEDKPTLNFFYQQVKNDYMLEIADQVDQEIALKLGCLEIRRSYGEMR
GNALEKKSNYEVLEKDVGLRRFFPKSLLDSVKAKTLRKLIQQTFRQFANL
NREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLT
DKGANPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSL
TIAENMADLIDGYCRLVNGATQSFIIRPGVRSHTDDYAEIIDEEDTYTMP
STRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCT
SDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSF
LQVRKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCV
KLGDFGLSRLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQ
GVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKA
QLSTILEEEKLQ
3D structure
PDB2j0k Structural Basis for the Autoinhibition of Focal Adhesion Kinase.
ChainB
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D546 A548 R550 N551 D564
Catalytic site (residue number reindexed from 1) D486 A488 R490 N491 D504
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4ST B I428 A452 V484 E500 L501 C502 E506 R550 L553 D564 I368 A392 V424 E440 L441 C442 E446 R490 L493 D504
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
Cellular Component
GO:0005856 cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2j0k, PDBe:2j0k, PDBj:2j0k
PDBsum2j0k
PubMed17574028
UniProtQ00944|FAK1_CHICK Focal adhesion kinase 1 (Gene Name=PTK2)

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