Structure of PDB 2iyk Chain B

Receptor sequence
>2iykB (length=155) Species: 9606 (Homo sapiens) [Search protein sequence]
LPIHACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKE
VTLHKDGPLGETVLECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQS
SLKDINWDSSQWQPLIQDRCFLSWLVKIPSEQEQLRARQITAQQINKLEE
LWKEN
3D structure
PDB2iyk Crystal Structure of the Upf2-Interacting Domain of Nonsense-Mediated Mrna Decay Factor Upf1.
ChainB
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C13 C35 H45 C6 C28 H38
BS02 ZN B S30 H49 C55 S23 H42 C48
BS03 ZN B C73 C76 C99 C103 C66 C69 C92 C96
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2iyk, PDBe:2iyk, PDBj:2iyk
PDBsum2iyk
PubMed16931876
UniProtQ92900|RENT1_HUMAN Regulator of nonsense transcripts 1 (Gene Name=UPF1)

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