Structure of PDB 2ix4 Chain B

Receptor sequence

>2ix4B (length=431) Species: 3702 (Arabidopsis thaliana)

RRVVVTGLGMVTPLGRGVETTWRRLIDGECGIRGLTLDDLKMKSFDEETK
LYTFDQLSSKVAAFVPYGSNPGEFDEALWLNSKAVANFIGYAVCAADEAL
RDAEWLPTEEEEKERTGVSIGGGIGSICDIVEAAQLICEKRLRRLSPFFI
PKILVNMASGHVSMKYGFQGPNHAAVTACATGAHSIGDATRMIQFGDADV
MVAGGTESSIDALSVAGFSRSRALSTKFNSSPQEASRPFDCDRDGFVIGE
GSGVIVLEEYEHAKRRGAKIYAELCGYGMSGDAHHITQPPEDGKGAVLAM
TRALRQSGLCPNQIDYVNAHATSTPIGDAVEARAIKTVFSEHATSGTLAF
SSTKGATGHLLGAAGAVEAIFSILAIHHGVAPMTLNVKNPDPIFDKRFMP
LTTSKKMLVRTAMSNSFGFGGTNASLLFASI

3D structure

• PDB: 2ix4 Structure of the Human Beta-Ketoacyl [Acp] Synthase from the Mitochondrial Type II Fatty Acid Synthase.
• Chain: B
• Resolution: 1.95 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C209 H350 E361 K384 H389 F447 F449
• Catalytic site (residue number reindexed from 1): C179 H320 E331 K354 H359 F417 F419
• Enzyme Commision number: 2.3.1.41: beta-ketoacyl-[acyl-carrier-protein] synthase I.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	6NA	B	I154 A208 C209 F248 G448 F449	I124 A178 C179 F218 G418 F419

Gene Ontology

Molecular Function

• GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
• GO:0016746 acyltransferase activity
• GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

Biological Process

• GO:0006633 fatty acid biosynthetic process
• GO:0010027 thylakoid membrane organization

Cellular Component

• GO:0005739 mitochondrion

External links

• PDB: RCSB:2ix4, PDBe:2ix4, PDBj:2ix4
• PDBsum: 2ix4
• PubMed: 17242430
• UniProt: Q8L3X9|KASM_ARATH 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (Gene Name=KAS)