Structure of PDB 2iqx Chain B

Receptor sequence

>2iqxB (length=185) Species: 10116 (Rattus norvegicus) [Search protein sequence]

AADISQWAGPLSLQEVDEPPQHALRVDYGGVTVDELGKVLTPTQVMNRPS
SISWDGLDPGKLYTLVLTDPDAPSRKDPKFREWHHFLVVNMKGNDISSGT
VLSEYVGSGPPKDTGLHRYVWLVYEQEQPLNCDEPILSNKSGDNRGKFKV
EEFRKKYHLGAPVAGTCFQAEWDDSVPKLHDQLAG

3D structure

PDB

2iqx Rat Phosphatidylethanolamine-Binding Crystal structure of Protein Containing the S153E Mutation in the Complex with o-Phosphorylethanolamine

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	OPE	B	D70 W84 H86 S109 G110 P111 Y120	D69 W83 H85 S108 G109 P110 Y119

Gene Ontology

	Molecular Function
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005102	signaling receptor binding
GO:0005524	ATP binding
GO:0008289	lipid binding
GO:0019899	enzyme binding
GO:0019900	kinase binding
GO:0019901	protein kinase binding
GO:0033612	receptor serine/threonine kinase binding
GO:0051019	mitogen-activated protein kinase binding

	Biological Process
GO:0000165	MAPK cascade
GO:0002026	regulation of the force of heart contraction
GO:0006979	response to oxidative stress
GO:0007286	spermatid development
GO:0009410	response to xenobiotic stimulus
GO:0009636	response to toxic substance
GO:0010466	negative regulation of peptidase activity
GO:0014823	response to activity
GO:0021766	hippocampus development
GO:0042755	eating behavior
GO:0043409	negative regulation of MAPK cascade
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045471	response to ethanol
GO:0045840	positive regulation of mitotic nuclear division
GO:0048240	sperm capacitation
GO:0051412	response to corticosterone
GO:0051591	response to cAMP
GO:0051592	response to calcium ion
GO:0051602	response to electrical stimulus
GO:0060409	positive regulation of acetylcholine metabolic process
GO:1905923	positive regulation of acetylcholine biosynthetic process

	Cellular Component
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0008021	synaptic vesicle
GO:0009986	cell surface
GO:0016020	membrane
GO:0043025	neuronal cell body
GO:0043679	axon terminus
GO:0045177	apical part of cell

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2iqx, PDBe:2iqx, PDBj:2iqx
PDBsum	2iqx
PubMed
UniProt	P31044\|PEBP1_RAT Phosphatidylethanolamine-binding protein 1 (Gene Name=Pebp1)

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