Structure of PDB 2iok Chain B

Receptor sequence
>2iokB (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTRASMMGLLTNLADRELVHMIN
WAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLL
LDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVY
TFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLL
ILSHIRHMSNKGMEHLYSPLYDLLLEML
3D structure
PDB2iok Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IOK B L1349 E1353 M1421 G1521 H1524 L1525 L40 E44 M112 G212 H215 L216 MOAD: ic50=1nM
BindingDB: IC50=1nM
External links
PDB RCSB:2iok, PDBe:2iok, PDBj:2iok
PDBsum2iok
PubMed17289385
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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