Structure of PDB 2ioc Chain B

Receptor sequence
>2iocB (length=220) Species: 10090 (Mus musculus) [Search protein sequence]
HGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPPPV
PRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAIL
LRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIA
ALKALEQASRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQA
LLQWVDEHARPFSTVKPMYG
3D structure
PDB2ioc The Crystal Structure of TREX1 Explains the 3' Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B D18 E20 H195 D200 D11 E13 H181 D186
BS02 D5M B D18 E20 A21 G23 L24 G80 A81 I84 Y129 H195 D11 E13 A14 G16 L17 G73 A74 I77 Y122 H181
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2ioc, PDBe:2ioc, PDBj:2ioc
PDBsum2ioc
PubMed17293595
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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