Structure of PDB 2ieh Chain B

Receptor sequence
>2iehB (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKT
YTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTM
EGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYN
EELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILE
KGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVD
LAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTS
IIATISPASLNLEETLSTLEYAHRAKNILNKPEVN
3D structure
PDB2ieh Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.4: Transferred entry: 5.6.1.3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B R26 P27 T107 G108 T109 G110 K111 T112 F113 E118 R11 P12 T92 G93 T94 G95 K96 T97 F98 E103
BS02 MOY B E116 G117 E118 R119 W127 D130 A133 Y211 L214 R221 E101 G102 E103 R104 W112 D115 A118 Y196 L199 R206 BindingDB: IC50=150nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:2ieh, PDBe:2ieh, PDBj:2ieh
PDBsum2ieh
PubMed17251189
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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