Structure of PDB 2i62 Chain B

Receptor sequence
>2i62B (length=261) Species: 10090 (Mus musculus) [Search protein sequence]
GFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKNLFKIFCLGA
VKGELLIDIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEPG
AFDWSPVVTYVCDLEGNRMKGPEKEEKLRRAIKQVLKCDVTQSQPLGGVS
LPPADCLLSTLCLDAACPDLPAYRTALRNLGSLLKPGGFLVMVDALKSSY
YMIGEQKFSSLPLGWETVRDAVEEAGYTIEQFEVISQNYSSTTSNNEGLF
SLVGRKPGRSE
3D structure
PDB2i62 The Crystal Structure of Mouse Nicotinamide N-methyltransferase in complex with SAH
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.1: nicotinamide N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B Y12 Y21 Y26 G64 S65 G66 T68 Y70 D86 Y87 T88 N91 D143 V144 T164 L165 A170 Y8 Y17 Y22 G60 S61 G62 T64 Y66 D82 Y83 T84 N87 D139 V140 T160 L161 A166
Gene Ontology
Molecular Function
GO:0008112 nicotinamide N-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006769 nicotinamide metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0031100 animal organ regeneration
GO:0032259 methylation
GO:0045722 positive regulation of gluconeogenesis
GO:0090312 positive regulation of protein deacetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2i62, PDBe:2i62, PDBj:2i62
PDBsum2i62
PubMed
UniProtO55239|NNMT_MOUSE Nicotinamide N-methyltransferase (Gene Name=Nnmt)

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