Structure of PDB 2i5x Chain B

Receptor sequence
>2i5xB (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
KTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPEN
RGKNRYNNILPYDATRVKLSNCSDYINASYIPGNNFRREYIVTQGPLPGT
KDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQM
LSESVLPEWTIREFKICGHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVR
DYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHD
LRLHRVHMVQTECQYVYLHQCVRDVLRARKL
3D structure
PDB2i5x Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1870 C1904 R1910 T1911 Q1948
Catalytic site (residue number reindexed from 1) D182 C216 R222 T223 Q260
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UA5 B D1870 H1871 C1904 S1905 A1906 V1908 G1909 R1910 D182 H183 C216 S217 A218 V220 G221 R222
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:2i5x, PDBe:2i5x, PDBj:2i5x
PDBsum2i5x
PubMed17139078
UniProtP23467|PTPRB_HUMAN Receptor-type tyrosine-protein phosphatase beta (Gene Name=PTPRB)

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