Structure of PDB 2i22 Chain B

Receptor sequence
>2i22B (length=178) Species: 562 (Escherichia coli) [Search protein sequence]
MYQDLIRNELNEAAETLANFLKDDANIHAIQRAAVLLADSFKAGGKVLSC
GNGGSHCDAMHFAEELTGRYRENRPGYPAIAISNDIFSRYVEAVGREGDV
LLGISTSGNSANVIKAIAAAREKGMKVITLTGKDGGKMAGTADIEIRVPH
FGYADRIQEIHIKVIHILIQLIEKEMVK
3D structure
PDB2i22 Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for Antibiotic Adjuvants
ChainB
Resolution2.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.3.1.28: D-sedoheptulose-7-phosphate isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I22 B G54 T120 A168 D169 Q172 G54 T106 A154 D155 Q158
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008968 D-sedoheptulose 7-phosphate isomerase activity
GO:0016853 isomerase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0097367 carbohydrate derivative binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009244 lipopolysaccharide core region biosynthetic process
GO:0051289 protein homotetramerization
GO:1901135 carbohydrate derivative metabolic process
GO:2001061 D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2i22, PDBe:2i22, PDBj:2i22
PDBsum2i22
PubMed18056714
UniProtP63224|GMHA_ECOLI Phosphoheptose isomerase (Gene Name=gmhA)

[Back to BioLiP]