Structure of PDB 2i0g Chain B

Receptor sequence
>2i0gB (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
LDALSPEQLVLTLLEAEPPHVLISRPASMMMSLTKLADKELVHMISWAKK
IPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRD
EGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVS
SRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKG
MEHLLNMKVPVYDLLLEMLNAH
3D structure
PDB2i0g Benzopyrans are selective estrogen receptor Beta agonists with novel activity in models of benign prostatic hyperplasia.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I0G B M295 E305 M336 I376 H475 L476 M30 E40 M71 I111 H203 L204 MOAD: Ki=0.19nM
BindingDB: Ki=0.19nM,EC50=0.66nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2i0g, PDBe:2i0g, PDBj:2i0g
PDBsum2i0g
PubMed17034120
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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