Structure of PDB 2hxh Chain B

Receptor sequence
>2hxhB (length=426) Species: 9823 (Sus scrofa) [Search protein sequence]
REIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYY
NEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNW
AKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLL
ISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYC
IDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLR
KLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMA
ACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKT
AVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGE
GMDEMEFTEAESNMNDLVSEYQQYQD
3D structure
PDB2hxh High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations
ChainB
Resolution11.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP B Q11 C12 Q15 S140 G142 T145 G146 D179 N206 Y224 N228 Q10 C11 Q14 S137 G139 T142 G143 D176 N203 Y221 N225
BS02 TA1 B V23 D26 E27 H229 L230 A233 S236 F272 P274 L275 T276 R278 P360 R369 G370 V22 D25 E26 H226 L227 A230 S233 F269 P271 L272 T273 R275 P357 R358 G359 BindingDB: EC50=520nM
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hxh, PDBe:2hxh, PDBj:2hxh
PDBsum2hxh
PubMed16946706
UniProtP02554|TBB_PIG Tubulin beta chain

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