Structure of PDB 2hwp Chain B

Receptor sequence
>2hwpB (length=239) Species: 9031 (Gallus gallus) [Search protein sequence]
DAWEIPRESLRLEVKLGQGEVWMGTWNGTTRVAIKTLQVMKKLRHEKLVQ
LYAVVSEEPIYIVTEYMSKGCLLDFLKGEMGKYLRLPQLVDMAAQIASGM
AYVERMNYVHRDLRAANILVGENLVCKVAFPIKWTAPEAALYGRFTIKSD
VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDL
MCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
3D structure
PDB2hwp Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.
ChainB
Resolution2.48 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 F424
Catalytic site (residue number reindexed from 1) D112 R114 A116 N117 F130
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DJK B C345 L393 C71 L119 BindingDB: IC50=>27000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2hwp, PDBe:2hwp, PDBj:2hwp
PDBsum2hwp
PubMed17334377
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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