Structure of PDB 2hsd Chain B

Receptor sequence
>2hsdB (length=253) Species: 1905 (Streptomyces exfoliatus) [Search protein sequence]
NDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELG
DAARYQHLDVTIEEDWQRVVAYAREEFGSVDGLVNNAGISTGMFLETESV
ERFRKVVEINLTGVFIGMKTVIPAMKDAGGGSIVNISSAAGLMGLALTSS
YGASKWGVRGLSKLAAVELGTDRIRVNSVHPGMTYTPMTAETGIRQGEGN
YPNTPMGRVGEPGEIAGAVVKLLSDTSSYVTGAELAVDGGWTTGPTVKYV
MGQ
3D structure
PDB2hsd The refined three-dimensional structure of 3 alpha,20 beta-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases.
ChainB
Resolution2.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G17 S139 Y152 K156
Catalytic site (residue number reindexed from 1) G16 S138 Y151 K155
Enzyme Commision number 1.1.1.53: 3alpha(or 20beta)-hydroxysteroid dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD B G13 R16 G17 L18 D37 V38 L39 L59 V61 N87 A88 I137 S139 Y152 K156 G183 T185 G12 R15 G16 L17 D36 V37 L38 L58 V60 N86 A87 I136 S138 Y151 K155 G182 T184
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase activity
Biological Process
GO:0008202 steroid metabolic process
GO:0008207 C21-steroid hormone metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2hsd, PDBe:2hsd, PDBj:2hsd
PDBsum2hsd
PubMed7922040
UniProtP19992|HSD_STREX 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase

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