Structure of PDB 2hof Chain B

Receptor sequence

>2hofB (length=316) Species: 10678 (Punavirus P1) [Search protein sequence]

SDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKLNNRKWFPAEPE
DVRDYLLYLQARGLAVKTIQQHLGQLNMLHRRSGLPRPSDSNAVSLVMRR
IRKENVDAGERAKQALAFERTDFDQVRSLMENSDRCQDIRNLAFLGIAYN
TLLRIAEIARIRVKDISRTDGGRMLIHIGRTATLVSTAGVEKALSLGVTK
LVERWISVSGVADDPNNYLFCRVRKNGVAAPSATSQLSTRALEGIFEATH
RLIYGAKDDSGQRYLAWSGHSARVGAARDMARAGVSIPEIMQAGGWTNVN
IVMNYIRNAMVRLLED

3D structure

PDB

2hof Synapsis of loxP sites by Cre recombinase.

Chain

Resolution

2.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	K43 M44 S47 R50 R81 L83 A84 K86 T87 Q90 R118 K132 R159 R173 R241 V242 K244 S257 R259 A260 R282 W315 T316 N317	K24 M25 S28 R31 R62 L64 A65 K67 T68 Q71 R99 K113 R140 R154 R222 V223 K225 S238 R240 A241 R263 W296 T297 N298	PDBbind-CN: Kd=8.9nM
BS02	dna	B	F37 S38 H40 T41 Q90 M97 R100 R101 R106 R121 I174 A175 A201 R243 N245 R259 E262 R282 Y283 S287 G288 H289	F18 S19 H21 T22 Q71 M78 R81 R82 R87 R102 I155 A156 A182 R224 N226 R240 E243 R263 Y264 S268 G269 H270	PDBbind-CN: Kd=8.9nM

Gene Ontology

	Molecular Function
GO:0003677	DNA binding

	Biological Process
GO:0006310	DNA recombination
GO:0015074	DNA integration

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2hof, PDBe:2hof, PDBj:2hof
PDBsum	2hof
PubMed	17573343
UniProt	P06956\|RECR_BPP1 Recombinase cre (Gene Name=cre)

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