Structure of PDB 2hk9 Chain B

Receptor sequence
>2hk9B (length=267) Species: 63363 (Aquifex aeolicus) [Search protein sequence]
MINAQTQLYGVIGFPVKHSLSPVFQNALIRYAGLNAVYLAFEINPEELKK
AFEGFKALKVKGINVTVPFKEEIIPLLDYVEDTAKEIGAVNTVKFENGKA
YGYNTDWIGFLKSLKSLIPEVKEKSILVLGAGGASRAVIYALVKEGAKVF
LWNRTKEKAIKLAQKFPLEVVNSPEEVIDKVQVIVNTTSVGLKDEDPEIF
NYDLIKKDHVVVDIIYKETKLLKKAKEKGAKLLDGLPMLLWQGIEAFKIW
NGCEVPYSVAERSVRDL
3D structure
PDB2hk9 Structural and biochemical analyses of shikimate dehydrogenase AroE from Aquifex aeolicus: implications for the catalytic mechanism.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.25: shikimate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP B V67 G130 G133 A134 N153 R154 T155 K158 T188 S189 V190 I214 M238 L239 V67 G130 G133 A134 N153 R154 T155 K158 T188 S189 V190 I214 M238 L239
BS02 SKM B S19 S21 N64 T66 K70 N91 D106 Y216 L239 Q242 S19 S21 N64 T66 K70 N91 D106 Y216 L239 Q242
Gene Ontology
Molecular Function
GO:0004764 shikimate 3-dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0019632 shikimate metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hk9, PDBe:2hk9, PDBj:2hk9
PDBsum2hk9
PubMed17649975
UniProtO67049|AROE_AQUAE Shikimate dehydrogenase (NADP(+)) (Gene Name=aroE)

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