Structure of PDB 2hfk Chain B

Receptor sequence
>2hfkB (length=277) Species: 54571 (Streptomyces venezuelae) [Search protein sequence]
AGMFRALFRQAVEDDRYGEFLDVLAEASAFRPQFASPEACSERLDPVLLA
GGPTDEGRAVLVGCTGTAANGGPHEFLRLSTSFQEERDFLAVPLPGYGTG
TALLPADLDTALDAQARAILRAAGDAPVVLLGHAGGALLAHELAFRLERA
HGAPPAGIVLVDPYPPGHQEPIEVWSRQLGEGLFAGELEPMSDARLLAMG
RYARFLAGPRPGRSSAPVLLVRASEPLGDWQEERGDWRAHWDLPHTVADV
PGDHFTMMRDHAPAVAEAVLSWLDAIE
3D structure
PDB2hfk Structural Basis for Macrolactonization by the Pikromycin Thioesterase
ChainB
Resolution1.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A148 G149 D176 H268
Catalytic site (residue number reindexed from 1) A134 G135 D162 H254
Enzyme Commision number 2.3.1.239: 10-deoxymethynolide syntase.
2.3.1.240: narbonolide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E4H B Y25 G149 S190 A217 L220 Y17 G135 S176 A203 L206
Gene Ontology
Biological Process
GO:0009058 biosynthetic process

View graph for
Biological Process
External links
PDB RCSB:2hfk, PDBe:2hfk, PDBj:2hfk
PDBsum2hfk
PubMed16969372
UniProtQ9ZGI2|PIKA4_STRVZ Narbonolide/10-deoxymethynolide synthase PikA4, module 6 (Gene Name=pikAIV)

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