Structure of PDB 2hb3 Chain B

Receptor sequence

>2hb3B (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]

PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGI
GGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF

3D structure

PDB

2hb3 Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance.

Chain

Resolution

1.35 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D25 T26 G27
Catalytic site (residue number reindexed from 1)	D25 T26 G27
Enzyme Commision number	3.4.23.4: chymosin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GRL	B	D25 G27 A28 D29 G48 G49 I50	D25 G27 A28 D29 G48 G49 I50	MOAD: Ki=0.0045nM PDBbind-CN: -logKd/Ki=11.35,Ki=4.5pM

Gene Ontology

	Molecular Function
GO:0004190	aspartic-type endopeptidase activity
GO:0042802	identical protein binding

	Biological Process
GO:0006508	proteolysis

External links