Structure of PDB 2h8k Chain B

Receptor sequence
>2h8kB (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
FNIMEVDGVPTLILSKEWWEKVCNFQAKPDDLILATYPKSGTTWMHEILD
MILNQLIKTHLPSHLIPPSIWKENCKIVYVARNPKDCLVSYYHFHRMASF
MPDPQNLEEFYEKFMSGKVVGGSWFDHVKGWWAAKDMHRILYLFYEDIKK
DPKREIEKILKFLEKDISEEILNKIIYHTSFDVMKQNPMTNYTTLPTSIM
DHSISPFMRKGMPGDWKNYFTVAQNEEFDKDYQKKMAGSTLTFRT
3D structure
PDB2h8k Structural and chemical profiling of the human cytosolic sulfotransferases.
ChainB
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K56 H117 S147
Catalytic site (residue number reindexed from 1) K39 H60 S90
Enzyme Commision number 2.8.2.1: aryl sulfotransferase.
2.8.2.2: alcohol sulfotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A3P B K56 S57 G58 T59 T60 W61 R139 S147 Y202 T236 F238 M241 R266 K267 G268 K39 S40 G41 T42 T43 W44 R82 S90 Y145 T179 F181 M184 R209 K210 G211
Gene Ontology
Molecular Function
GO:0004027 alcohol sulfotransferase activity
GO:0004062 aryl sulfotransferase activity
GO:0005515 protein binding
GO:0008146 sulfotransferase activity
GO:0016740 transferase activity
GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006790 sulfur compound metabolic process
GO:0006805 xenobiotic metabolic process
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923 sulfation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2h8k, PDBe:2h8k, PDBj:2h8k
PDBsum2h8k
PubMed17425406
UniProtQ6IMI6|ST1C3_HUMAN Sulfotransferase 1C3 (Gene Name=SULT1C3)

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