Structure of PDB 2h5e Chain B

Receptor sequence
>2h5eB (length=479) Species: 562 (Escherichia coli) [Search protein sequence]
TLSPYLQEVAKRRTFAIISHPDAGKTTITEKVLLFGQTTSVMQFPYHDCL
VNLLDTPGHEDFSEDTYRTLTAVDCCLMVIDAAKGVEDRTRKLMEVTRLR
DTPILTFMNKLDRDIRDPMELLDEVENELKIGCAPITWPIGCGKLFKGVY
HLYKDETYLYQSGKGHTIQEVRIVKGLNNPDLDAAVGEDLAQQLRDELEL
VKGASNEFDKELFLAGEITPVFFGTALGNFGVDHMLDGLVEWAPAPMPRQ
TDTRTVEASEDKFTGFVFKIQARVAFMRVVSGKYEKGMKLRQVRTAKDVV
ISDALTFMAVEEAYPGDILGLHNHGTIQIGDTFTQGEMMKFTGIPNFAPE
LFRRIRLKDKQLLKGLVQLSEEGAVQVFRPISNNDLIVGAVGVLQFDVVV
ARLKSEYNVEAVYESVNVATARWVECADAKKFEEFKRKNESQLALDGGDN
LAYIATSMVNLRLAQERYPDVQFHQTREH
3D structure
PDB2h5e RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D23
Catalytic site (residue number reindexed from 1) D22
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP B D23 G25 K26 T27 T28 H92 N142 K143 D145 T258 A259 L260 D22 G24 K25 T26 T27 H59 N109 K110 D112 T225 A226 L227
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016149 translation release factor activity, codon specific
GO:0016150 translation release factor activity, codon nonspecific
GO:0019003 GDP binding
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006412 translation
GO:0006415 translational termination
GO:0006449 regulation of translational termination
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2h5e, PDBe:2h5e, PDBj:2h5e
PDBsum2h5e
PubMed17540173
UniProtP0A7I4|RF3_ECOLI Peptide chain release factor RF3 (Gene Name=prfC)

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