Structure of PDB 2h4y Chain B

Receptor sequence
>2h4yB (length=87) Species: 9606 (Homo sapiens) [Search protein sequence]
IKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVE
EIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
3D structure
PDB2h4y An allosteric circuit in caspase-1.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) E390
Catalytic site (residue number reindexed from 1) E73
Enzyme Commision number 3.4.22.36: caspase-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B S339 W340 R341 H342 R383 S22 W23 R24 H25 R66
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2h4y, PDBe:2h4y, PDBj:2h4y
PDBsum2h4y
PubMed18590738
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

[Back to BioLiP]