Structure of PDB 2h2p Chain B

Receptor sequence
>2h2pB (length=441) Species: 562 (Escherichia coli) [Search protein sequence]
RRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGA
LVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGALE
DQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIFR
LKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIKA
VFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFGP
IFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGGF
NLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVL
GTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMTD
NYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEA
3D structure
PDB2h2p Uncoupling of a CLC Cl(-)/H(+) Exchange Transporter by Polyatomic Anions
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SEK B G106 S107 F348 I448 G89 S90 F331 I431
BS02 SEK B L274 A447 L257 A430
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
GO:0015297 antiporter activity
GO:0042802 identical protein binding
GO:0062158 chloride:proton antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990451 cellular stress response to acidic pH
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:2h2p, PDBe:2h2p, PDBj:2h2p
PDBsum2h2p
PubMed16905147
UniProtP37019|CLCA_ECOLI H(+)/Cl(-) exchange transporter ClcA (Gene Name=clcA)

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