Structure of PDB 2h1h Chain B

Receptor sequence
>2h1hB (length=315) Species: 439184 (Escherichia coli RS218) [Search protein sequence]
MRVLIVKTSSMGDVLHTLPALTDAQQAIPGIKFDWVVEEGFAQIPSWHAA
VERVIPVAIRRWRKAWFSAPIKAERKAFREALQAKNYDAVIDAQGLVKSA
ALVTRLAHGVKHGMDWQTAREPLASLFYNRKHHIAKQQHAVERTRELFAK
SLGYSKPQTQGDYAIAQHFLTNLPTDAGEYAVFLHATTRDDKHWPEEHWR
ELIGLLADSGIRIKLPWGAPHEEERAKRLAEGFAYVEVLPKMSLEGVARV
LAGAKFVVSVDTGLSHLTAALDRPNITVYGPTDPYGKNQMVCRAPGNELS
QLTANAVKQFIEENA
3D structure
PDB2h1h Structure of the Escherichia coli heptosyltransferase WaaC: binary complexes with ADP and ADP-2-deoxy-2-fluoro heptose.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.99.23: lipopolysaccharide heptosyltransferase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AFH B A186 T187 T188 K192 W217 G218 E222 D261 T262 G263 L264 H266 A186 T187 T188 K192 W217 G218 E222 D261 T262 G263 L264 H266 MOAD: ic50=30uM
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008713 ADP-heptose-lipopolysaccharide heptosyltransferase activity
GO:0008920 lipopolysaccharide heptosyltransferase activity
GO:0016757 glycosyltransferase activity
Biological Process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009244 lipopolysaccharide core region biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

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External links
PDB RCSB:2h1h, PDBe:2h1h, PDBj:2h1h
PDBsum2h1h
PubMed16963083
UniProtP24173|WAAC_ECOLI Lipopolysaccharide heptosyltransferase 1 (Gene Name=waaC)

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