Structure of PDB 2gwh Chain B

Receptor sequence

>2gwhB (length=288) Species: 9606 (Homo sapiens)

KRLSVNYVKGILQPTDTCDIWDKIWNFQAKPDDLLISTYPKAGTTWTQEI
VELIQNEGDVEKSKRAPTHQRFPFLEMKIPSLGSGLEQAHAMPSPRILKT
HLPFHLLPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEE
YFETFLAGKVCWGSWHEHVKGWWEAKDKHRILYLFYEDMKKNPKHEIQKL
AEFIGKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEIMDHSISPFMR
KGAVGDWKKHFTVAQNERFDEDYKKKMTDTRLTFHFQF

3D structure

• PDB: 2gwh Structural and chemical profiling of the human cytosolic sulfotransferases.
• Chain: B
• Resolution: 1.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K55 H115 S145
• Catalytic site (residue number reindexed from 1): K41 H101 S131
• Enzyme Commision number: 2.8.2.1: aryl sulfotransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A3P	B	K55 G57 T58 T59 W60 R137 S145 Y200 F236 M263 R264 K265 G266	K41 G43 T44 T45 W46 R123 S131 Y186 F222 M249 R250 K251 G252
BS02	PCI	B	F88 K113 H115 F149 N153 W176 Y247 M255	F74 K99 H101 F135 N139 W162 Y233 M241
BS03	PCI	B	K229 H232	K215 H218

Gene Ontology

Molecular Function

• GO:0004062 aryl sulfotransferase activity
• GO:0008146 sulfotransferase activity
• GO:0016740 transferase activity

Biological Process

• GO:0006068 ethanol catabolic process
• GO:0006805 xenobiotic metabolic process
• GO:0009812 flavonoid metabolic process
• GO:0044598 doxorubicin metabolic process
• GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
• GO:0051923 sulfation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:2gwh, PDBe:2gwh, PDBj:2gwh
• PDBsum: 2gwh
• PubMed: 17425406
• UniProt: O75897|ST1C4_HUMAN Sulfotransferase 1C4 (Gene Name=SULT1C4)