Structure of PDB 2gru Chain B

Receptor sequence
>2gruB (length=360) Species: 1397 (Niallia circulans) [Search protein sequence]
TTKQICFADRCFNFAFGEHVLESVESYIPRDEFDQYIMISDSGVPDSIVH
YAAEYFGKLAPVHILRFQGGEEYKTLSTVTNLQERAIALGANRRTAIVAV
GGGLTGNVAGVAAGMMFRGIALIHVPTTFLAASDSVLSIKQAVNLTSGKN
LVGFYYPPRFVFADTRILSESPPRQVKAGMCELVKNMLILENDNKEFTED
DLNSANVYSPKQLETFINFCISAKMSVLSEDIYEKKKGLIFEYGHTIGHA
IELAEQGGITHGEAIAVGMIYAAKIANRMNLMPEHDVSAHYWLLNKIGAL
QDIPLKSDPDSIFHYLIHDNDEDNLGMILLSGVGKPAMYNQTLLTPVRKT
LIKEVIREGL
3D structure
PDB2gru Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+
ChainB
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R119 K141 E183 K225 E235 G239 E243 H246 H250 H262
Catalytic site (residue number reindexed from 1) R118 K140 E182 K224 E234 G238 E242 H245 H249 H261
Enzyme Commision number 4.2.3.124: 2-deoxy-scyllo-inosose synthase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003856 3-dehydroquinate synthase activity
GO:0016829 lyase activity
GO:0016838 carbon-oxygen lyase activity, acting on phosphates
GO:0046872 metal ion binding
Biological Process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0017000 antibiotic biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2gru, PDBe:2gru, PDBj:2gru
PDBsum2gru
PubMed17879343
UniProtQ9S5E2|DOIS_NIACI 2-deoxy-scyllo-inosose synthase (Gene Name=btrC)

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