Structure of PDB 2gqs Chain B

Receptor sequence
>2gqsB (length=237) Species: 562 (Escherichia coli) [Search protein sequence]
MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVN
NKFNYFIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGS
LVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLAR
MKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEFSPDGSRL
WDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD
3D structure
PDB2gqs Nucleotide Complexes of Escherichia coli Phosphoribosylaminoimidazole Succinocarboxamide Synthetase.
ChainB
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B E90 D129 E90 D129
BS02 MG B E90 D129 E90 D129
BS03 ADP B Y8 G10 K11 A12 K13 L24 Q69 L84 M86 K123 D191 Y8 G10 K11 A12 K13 L24 Q69 L84 M86 K123 D191
BS04 C2R B E90 R94 G99 S100 D175 K177 D196 G197 S198 R199 R215 E90 R94 G99 S100 D175 K177 D196 G197 S198 R199 R215
Gene Ontology
Molecular Function
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009236 cobalamin biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:2gqs, PDBe:2gqs, PDBj:2gqs
PDBsum2gqs
PubMed16687397
UniProtP0A7D7|PUR7_ECOLI Phosphoribosylaminoimidazole-succinocarboxamide synthase (Gene Name=purC)

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