Structure of PDB 2gpp Chain B

Receptor sequence

>2gppB (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]

PYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGW
AKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIM
DEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHI
EDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAV
QHFYNIKLEGKVPMHKLFLEMLEA

3D structure

PDB

2gpp X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	I280 G281 K284 M298 K448 L449 E452	I48 G49 K52 M66 K216 L217 E220

External links

PDB	RCSB:2gpp, PDBe:2gpp, PDBj:2gpp
PDBsum	2gpp
PubMed	16990259
UniProt	P62508\|ERR3_HUMAN Estrogen-related receptor gamma (Gene Name=ESRRG)

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