Structure of PDB 2gfd Chain B

Receptor sequence
>2gfdB (length=217) Species: 9615 (Canis lupus familiaris) [Search protein sequence]
EKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDE
NALAGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAGTSEFL
NKMTEAQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNE
FSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPI
YVWSSKTKTVWDWELMN
3D structure
PDB2gfd Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RDA B N107 A111 D149 M154 N162 I166 V197 F199 Y200 T245 I247 N34 A38 D76 M81 N89 I93 V118 F120 Y121 T166 I168 MOAD: Kd=0.52uM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:2gfd, PDBe:2gfd, PDBj:2gfd
PDBsum2gfd
PubMed19361515
UniProtP41148|ENPL_CANLF Endoplasmin (Gene Name=HSP90B1)

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