Structure of PDB 2gb4 Chain B

Receptor sequence
>2gb4B (length=230) Species: 10090 (Mus musculus) [Search protein sequence]
AEVQKNQVLTLEDWKEKWVTRHISFHQEQGHQLLKKHLDTFLKGQSGLRV
FFPLCGKAIEMKWFADRGHTVVGVEISEIGIREFFAEQNLSYTEEPLAEI
AGAKVFKSSSGSISLYCCSIFDLPRANIGKFDRIWDRGALVAINPGDHDR
YADIILSLLRKEFQYLVAVLSYDPTKHAGPPFYVPSAELKRLFGTKCSMQ
CLEEVDALEERHKAWGLDYLFEKLYLLTEK
3D structure
PDB2gb4 Crystal structure of Thiopurine methyltransferase (18204406) from Mus musculus at 1.35 A resolution
ChainB
Resolution1.25 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.67: thiopurine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B L21 W24 W28 F35 L64 C65 E85 I86 S129 I130 R147 G148 L11 W14 W18 F25 L54 C55 E75 I76 S119 I120 R137 G138
Gene Ontology
Molecular Function
GO:0008119 thiopurine S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
Biological Process
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2gb4, PDBe:2gb4, PDBj:2gb4
PDBsum2gb4
PubMed
UniProtO55060|TPMT_MOUSE Thiopurine S-methyltransferase (Gene Name=Tpmt)

[Back to BioLiP]